Spandan 2013

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PHARMAVENTURE2013

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Computer aided drug design (CADD)

 Computer aided drug design (CADD) exploits state of art technologies to speed upthe drug development process. Molecular modelling and computational chemistry are assuming an increasing important role in understanding the basis of drug receptor interaction and assisting the medicinal chemists in the design of new therapeutic agent. Traditional drug development has demerits like random screening, chance discovery, a typical process for a drug is approx. 12 years and    expenditure is over $ 300 million. CADD is one of the tools which can be used to increase the efficiency of a drug discovery process. CADD has advantages like target specific and 3D structure based, fast and automatic, very low cost and high success rate. CADD helps in better understanding the details of the problem and to refine their approach and it helps to guide further experimental planning and potentially makes this process more efficient. CADD can be beneficial to find cure for diseases like cancer and AIDS. Cancer causing H- Ras p²¹ mutant protein can be studied by this technology. In HIV, it is proved that there are 87 HIV proteases deposited, whose active sites and important polypeptide chain are different. Many pharmaceutical industry have started  using CADD as a tool of the discovery. The addition of CADD technologies to the research and drug discovery approaches could lead to a reduction of up to 50% cost in the drug design.

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TOP 200 PHARMA COMPANIES PROFILE

                                                         Preface
The report on Indian Pharma company profiles contains Top 200 Indian
pharmaceutical companies  based on their revenues. The information on
the companies are obtained from their respective company websites, annual reports,
financial information available in public domain and paid databases. The latest information is
captured to the extent possible, depending on the availability. In the absence of availability of
latest financials of the companies, old data has been retained. The profiles attempt to provide
a comprehensive business information about the company. The vital facts captured include
business profile/major therapeutic segments, names of the directors, subsidiaries and
agreement/alliances. The companies’ R&D facilities and financial highlights are given for the
last five years.
The report will benefit researchers and students gathering business intelligence about Indian
Pharma companies and will help Pharma companies to understand their competitors from

business perspective. Foreign investors will get primary information about major pharma
companies in India with latest financials and other vital inputs.
While every possible effort has been made to ensure accuracy of the information.


200 Pharma Companies Profile
© Business Consulting & Research Pvt. Ltd.

                                                      CONTENTS
1. AREY DRUGS AND PHARMACEUTICALS LIMITED
2. ARTI DRUGS LTD
3. ARTI HEALTHCARE LTD
4. BBOTT INDIA LIMITED
5. BL BIOTECHNOLOGIES LTD
6. DVIK LABORATORIES
7. GIO PHARMACEUTICALS LTD
8. HLCON PARENTERALS (INDIA) LTD
9. JANTA PHARMA LTD.
10. ALBERT DAVID LTD.
11. ALEMBIC LTD
12. ALPHA DRUG INDIA LTD
13. ALTA LABORATORIES LTD
14. AMBALAL SARABHAI ENTERPRISES LTD
15. AMRUTANJAN HEALTHCARE LTD
16. ANGLO-FRENCH DRUGS & INDUSTRIES LTD
17. ANKUR DRUGS LTD
18. ANUH PHARMA LTD
19. APEX LABORATORIES LTD
20. ARVIND REMEDIES LTD
21. ASTRAZENECA PHARMA INDIA LTD
22. ATUL LIMITED
23. AURO LABORATORIES LTD
24. AUROBINDO PHARMA LTD
25. AVENTIS PHARMA LIMITED
26. AVINASH DRUGS LTD
27. BAJAJ CONSUMER CARE LTD
28. BAL PHARMA LTD
29. BDH INDUSTRIES LTD
30. BERYL DRUGS LTD
31. BHARAT IMMUNOLOGICALS AND BIOLOGICALS CORPORATION LTD.
32. BHARAT SERUMS & VACCINES LTD
33. BIOCON LIMITED
34. BIOLOGICAL E LIMITED
35. BLUE CROSS PHARMACEUTICALS LTD
36. BRABOURNE ENTERPRISES
37. CADILA HEALTHCARE LTD
38. CADILA PHARMACEUTICALS LTD
39. CAPLIN POINT LABORATORIES LTD
40. CAPSUGEL HEALTHCARE LTD
41. CIPLA LTD
42. CLARIS LIFE SCIENCES LTD
43. COLINZ LABORATORIES LTD
44. CONCORD DRUGS LTD
45. CORAL LABORATORIES LIMITED
46. CORE HEALTHCARE LTD

200 Pharma Companies Profile
© Business Consulting & Research Pvt. Ltd.

47. DABUR PHARMA LTD
48. DATT MEDIPRODUCTS LTD
49. DEY’S MEDICAL STORES MFG. LTD
50. DIL LTD
51. DISHMAN PHARMACEUTICALS & CHEMICALS
52. DIVI’S LABORATORIES LTD
53. DOCTORS ORGANIC AND CHEMICALS LTD
54. DR. REDDY’S LABORATORIES LTD
55. EAST INDIA PHARMACETUICALS WORKS LTD
56. ELDER HEALTHCARE LTD
57. ELDER PHARMACEUTICALS LTD
58. EMAMI LTD
59. EMCURE PHARMACEUTICALS LTD
60. EMMELLEN BIOTECH PHARMACEUTICALS LTD
61. EVEREST ORGANICS LTD
62. FDC LTD
63. FERMENTA BIOTECH LTD
64. FLAMINGO PHARMACEUTICALS
65. FREDUN PHARMA LTD
66. FULFORD (I) LTD
67. GLENMARK PHARMACEUTICALS LTD
68. GODAVARI DRUGS LTD
69. GRANULES INDIA LIMITED
70. GROUP PHARMACEUTICALS LTD
71. GLAXO SMITHKLINE PHARMACEUTICALS LTD
72. GUFIC BIOSCIENCE LTD
73. GUJARAT THEMIS BIOSYN LTD
74. HAFFKINE AJNITHA PHARMACEUTICAS LTD
75. HAFFKINE BIO-PHARMACEUTICAL CORPORATION LTD
76. HARLEYSTREET PHARMACEUTICALS LTD
77. HARMAN FINOCHEM LTD
78. HESTER BIOSCIENCES LTD
79. HETERO DRUGS
80. HIKAL LTD
81. HIRAN ORGOCHEM LTD
82. IND-SWIFT LABORATORIES LTD
83. INDOCO REMEDIES LTD
84. IND SWIFT LTD
85. INTAS PHARMA LTD
86. IPCA LABORATAORIES LTD
87. ISHITA DRUGS AND INDUSTRIES LTD
88. J.K. PHARMACHEM LTD
89. JAGSONPAL PHARMACEUTICAL LTD
90. JB CHEMICALS & PHARMACEUTICALS
91. JENBURKT PHARMACEUTICALS LTD
92. JUPITER BIOSCIENCE LTD
93. KAMRON LABORATORIES LTD
94. KAPPAC PHARMA LTD
95. KDL BIOTECH LTD

200 Pharma Companies Profile
©  Business Consulting & Research Pvt. LTD.

96. KERALA AYURVEDA PHARMACY LTD
97. KILITCH DRUGS (I) LTD
98. KONAR ORGANICS LTD
99. KOPRAN LIMITED
100. KREBS BIOCHEMICALS & INDUSTRIES LIMITD
101. 00. KUDOS CHEMIE LTD
102. LINCOLN PHARMACEUTICALS LTD.
103. TWILIGHT LI-TAKA PHARMACEUTICALS LTD
104. LUPIN LTD.
105. LYKA LABS LTD
106. MACLEODS PHARMACEUTICALS
107. MAKERS LABORATORIES LTD.
108. MANGALAM DRUGS AND ORGANICS LTD.
109. MARKSANS PHARMA LTD
110. MATRIX LABORATORIES LTD.
111. MEDI CAPS LIMITED
112. MEDICAMEN BIOTECH LTD.
113. MEDLEY PHARMACEUTICALS LTD
114. MERCK LTD, INDIA
115. MERCURY LABORATORIES LTD.
116. MONOZYME INDIA LTD.
117. MOREPEN LABORATORIES LTD.
118. NATCO PHARMACEUTICALS LTD.
119. NECTAR LIFESCIENCES LTD.
120. NEON LABORATORIES LTD
121. NEULAND LABORATORIES LTD
122. NGL FINE-CHEM LTD.
123. PIRAMAL HEALTH CARE .
124. NOVARTIS INDIA
125. ORCHID CHEMICALS AND PHARMACEUTICALS LTD
126. ORGANON INDIA
127. ORTIN LABORATORIES LTD
128. OZONE PHARMACEUTICALS LTD.
129. PROCTER & GAMBLE HYGIENE AND HEALTHCARE LTD
130. P I DRUGS AND PHARMACEUTICALS LTD
131. PAN DRUGS LTD.
132. PANACEA BIOTECH LTD.
133. PANJON LTD.
134. PARAS PHARMACEUTICALS LTD
135. PARENTERAL DRUGS (INDIA) LTD.
136. PERK PHARMACEUTICALS LTD.
137. PFIZER LTD.
138. PHAARMASIA LTD.
139. PHARMAIDS PHARMACEUTICALS LTD.
140. PLETHICO PHARMACEUTICALS LTD.
141. PRINCIPAL PHARMACEUTICALS AND EXPORTS LTD.
142. PRUDENTIAL PHARMACEUTICAS LTD.
143. PUNJAB CHEMIALS & CROP PROTECTION LTD
144. RANBAXY LABORATORIES LTD

200 Pharma Companies Profile
©  Business Consulting & Research Pvt. LTD.

145. RAPTAKOS, BRETT & CO.LTD
146. ROOPA INDUSTRIES LTD
147. RUBRA MEDICAMENTS LTD
148. RUSAN PHARMA LTD
149. SAMRAT PHARMACHEM LIMITED
150. SANDU PHARMACEUTICALS LTD
151. SANGAM HEALTHCARE LTD
152. SANJIVANI PARENTERALS LTD.
153. SENBO INDUSTRIES LTD
154. SHARON BIO-MEDICINE LTD
155. SHASUN CHEMICALS & DRUGS LTD
156. SHILPA MEDICARE LTD
157. SIGMA LABORATORIES LTD
158. SIRIS LTD…
159. SMRUTHI ORGANICS LTD
160. S M S PHARMACEUTICALS LTD.
161. SOLVAY PHARMA INDIA LTD
162. SPAN DIAGNOSTICS LTD.
163. SS ORGANICS LTD.
164. STERLING BIOTECH LTD.
165. STRIDES ARCOLAB LTD
166. SUN PHARMACEUTICAL INDUSTRIES LTD
167. SUNIL HEALTHCARE LTD
168. SURYA PHARMACEUTICALS LTD
169. SUVEN LIFE SCIENCES LTD
170. SYNCOM FORMULATIONS (INDIA) LTD
171. TABLETS INDIA LTD
172. THEMIS MEDICARE LTD
173. TONIRA PHARMA LTD
174. TORRENT GUJARAT BIOTECH LIMITED
175. TORRENT PHARMACEUTICALS LIMITED
176. TRANSCHEM LTD
177. TTK HEALTHCARE LTD
178. USV LIMITED
179. UNICHEM LABORATORIES LTD
180. UNIMARK REMEDIES LTD
181. UNI-SANKYO LTD
182. UNJHA FORMULATIONS LTD
183. VARDHMAN LABORATORIES LTD
184. VENKAT PHARMA LTD
185. VENUS REMEDIES LTD
186. VERONICA LABORATORIES LIMITED
187. VIKRAM THERMO INDIA LTD
188. VIMTA LABS LTD
189. VINATI ORGANICS LTD
190. VISTA PHARMACEUTICALS LTD
191. VIVIMED LABS LTD
192. VYSALI PHARMACEUTICALS LTD
193. WANBURY LTD
194. WOCKHARDT LIMITED
195. WYETH LABORATORIES LTD
196. YENKEY DRUGS AND PHARMACEUTICALS LTD
197. ZANDU PHARMACEUTICAL WORKS LTD
198. ZENITH HEALTHCARE LTD
199. ZENOTECH LABORATORIES LTD
200. ZORAPHARMA LTD.


200 Pharma Companies Profile
©  Business Consulting & Research Pvt. Ltd.

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Supercritical Fluid (SCF) Systems

Supercritical Fluid (SCF) technology works! With today's innovative, easy-to-use systems from Applied Separations, your idea will be tomorrow's green process! No petroleum solvents and no toxic residue.

We have built thousands of SFE systems. Get the benefit of our experience. You have the ideas, we have the SFE systems - from conception to production. From laboratory systems to pilot plants to large scale production facilities.

Applications and process support?  Discuss your ideas with us. 

A few examples include:

• Extracting herbs, spices and fragrances
• Extraction of pharmaceuticals / nutraceuticals
• Extracting nicotine and caffeine
• Extraction from foods
• Dyeing textiles
• Cleaning medical implants
• Making nanoparticles
• Drying aerogels
• Cleaning wafers
• Developing photoresists
• Extraction from polymers
• Impregnation of biopolymers

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Supercritical Fluid Tech

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Drug Safety

When it comes to medicines, safety means many things to many people. Volunteers in clinical trials, researchers and technicians working in laboratories and manufacturing facilities, regulators at the food and drug Administration physicians prescribing medicines, and patients who rely on those therapies to lead healthier, longer lives -- all have vested interests in safety. Nothing is more important to America’s biopharmaceutical research companies than the safety and integrity of the medical products they develop.

Ensuring the safety of a medicine begins long before a therapy enters the marketplace and continues long after it is available to patients. During the discovery and development

 of a potential medicine, safety is established incrementally through laboratory tests, studies with small numbers of volunteer patients, and carefully controlled and monitored clinical trials.

Throughout the review process, the FDA evaluates new medicines to determine that the health benefits outweigh emerging risks. And biopharmaceutical research companies, the FDA, healthcare providers and patients all play crucial roles in monitoring the safety of approved medicines.

According to the FDA, about 97 percent of the medicines it has approved over the past two decades are still on the market and considered safe. While this is a solid collective track record, America’s biopharmaceutical companies continuously strive to make a good system even better.

The proper use of medicines also is a critical element of patient safety and something that companies continue to stress. Innovative medicines can extend and enhance patient lives, but they also can be dangerous if misused or abused. Promoting adherence to prescribed treatments, reducing prescription drug abuse, and fostering prompt and safe disposal of unused medicines are ongoing priorities for biopharmaceutical research companies and other healthcare stakeholders.

Member companies also continue to work with key government agencies, such as the FDA and Homeland Security Department, and with congressional leaders to help safeguard patient health and the U.S. drug supply.

Although America’s medicine supply remains the safest in the world, no country is immune to the global threat of counterfeit medicines. The most common means forcounterfeit drugs to enter the United States is through purchases made on illegal online pharmacy websites operated by criminals in countries that have known counterfeiting problems. Targeting these illegal websites can help protect patient safety and ensure that the closed U.S. drug-supply system is not compromised.

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OTC Drugs

Over-the-counter (OTC) medicines are drugs you can buy without a prescription. Some OTC medicines relieve aches, pains and itches. Some prevent or cure diseases, like tooth decay and athlete's foot. Others help manage recurring problems, like migraines.

In the United States, the Food and Drug Administration decides whether a medicine is safe enough to sell over-the-counter. Taking OTC medicines still has risks. Some interact with other medicines, supplements, foods or drinks. Others cause problems for people with certain medical conditions. If you're pregnant, talk to your health care provider before taking any medicines.

It is important to take medicines correctly. More medicine does not necessarily mean better. You should never take OTC medicines longer or in higher doses than the label recommends. If your symptoms don't go away, it’s a clear signal that it's time to see your healthcare provider.
Link for that
s I had promised some time back, I am proposing a OTC list for India.
I am also proposing a new category for India, i.e. the P-list (Pharmacy
medicines), which would be a shot-in-the-arm weaponry for the
Pharmacist to dispense & recommend these medicines as per his
discretion.

My suggestions to you :
1) This is a trial list, to be built up (additions, deletions) with the
assistance of I-druggers, and eventually, other experts, and other
stakeholders in the country. It could be proposed to submit this list
eventually to the Indian FDA, for their decision. Let the I-druggers
decide too, to whom these lists need to be circulated for comments and
debate, etc.......
2) I have not included FDCs for obvious reasons. However, it would be
a gigantic, and near impossible task to remove all these "irrational"
FDCs from the market. It needs to be decided what is to be done of
these FDC OTC drugs.
3) Initially I tried to restrict myself to OTC drugs from the WHO EDL &
india's EDL 2003, however, the list became too small, and would not
sound practicable to the huge commercial market. So, there are many
drugs which do not figure in these lists.
4) I now hope that this is a commencement of a whole new exercise in
India's drug history........

Description of OTC :

Non- Prescription medicines (OTC medicines) ? These medicines can be
sold only at a pharmacy (and not in any other shop).
These need not be dispensed under the direct supervision of a
pharmacist.
These medicines can be advertised to the public, but without making
tall claims, or misleading the public. All advertisements should also
contain the Warning messages 1. ? DO not use for more than a week
without consulting your doctor or pharmacist)?
2. ?All medicines have the potential to have adverse effects in any
individual?.
In addition to the 2 above messages, the label of the medicine should
also contain :
1. Any contra-indications for use.
2. Indications, dosage, frequency of dose.
3. Potential adverse effects (those which can be ignored, and those if
seen by the patient, he should stop taking the medicine.

In addition, it would be of advantage if PIL or PPI (patient oriented
information) is enclosed in the package ? containing more information
of the medicine. (This PPI or PIL has to be approved by the DCGI). It
is preferable that such information be mandatory.

[India-drug] OTC and P drug list

Aspirin 300mg
Albendazole tab 400mg
Aluminium Hydroxide + Magnesium hydroxide
Activated dimethicone tab 40 mg
Ascorbic acid 100mg, 500mg
Bisacodyl tab 5mg
Castor Oil
Calcium salts 125mg. 250 mg
Chloroquinine sulphate tab 150mg tab
Diethylcarbamazine 50mg , 100 mg tab
Eucalyptus Oil
Ferrous salts tab eq. to 60mg elemental iron
Folic acid tab 500 mcg
Glycerine
Ibuprofen tab 200 mg
Ipecac syrup
Isapghula husk 3.5 gm per 5.6 gm ;powder
Lactulose Liquid 10g/15ml
Loperamide 2 mg
Milk of Magnesia tablets, liquid
Magnesium sulphate powder
Nicotinamide tabs 50mg*
Oral Rehydration Salts
Paracetamol tab 500 mg, syrup 125mg/5ml
Pseudoephedrine tab 60 mg, Syrup 30mg/5ml
Pyridoxine Hydrochloride tab 5mg, 25mg
Riboflavin tab 5mg
Senna tabs 12mg,18 mg
Sodium Bicarbonate powder
Thiamine tab 100mg
Vitamin A tab 5000 IU
Vitamin D3 400 I.U. (capsules)
Vitamin E Cap 200mg
Amylmetacresol lozenges
Benzalkonium chloride lozenges, max 600mcg
Borax (sodium borate ) opthalmic lotions 0.7%
Choline Salicylate mouth gel 8.7%
Cetylpyridinium chloride lozenges, mouth gel
Chlorhexidine gluconate solution 0.2%, gel
Glycerine Suppositories
Povidone-iodine germicide gargle 1% w/v
Oxymetazoline hydrochloride 0.05% nasal drops
Xylometazoline 0.1% nasal drops
OTC DRUGS FOR EXTERNAL USE (including antiseptics/disinfectants)
Benzyl benzoate 25% lotion
Benzoin compound Tincture
Bleaching powder
Calamine Lotion
Cetrimide solution 20 % conc. For dilution
Chlorhexidine solution 5 % conc. For dilution
Chloroxylenol cream 0.8%
Chloroxylenol solution 4.8%
Clotrimazole cream, lotion
Crotamiton cream 10%
Emulsifying ointment
Emusifying wax
Gentian violet 0.5 %, 1 %aqueous solution
Guiaphensin Sy
Hydrogen peroxide solution
Hydrous emulsifying ointment
Iodine Tincture
IPA (isopropyl Alcohol) 70 %
Lindane lotion 1 % (GBHC), cream 1 %
Mercurochrome 0.2 %
Methylated Ethyl Alcohol 70 %
Methyl salicylate ointment
Miconazole 2 % cream or ointment
Permethrin rinse 1 % (Lotion/shampoo)
Potassium Permanganate
Povidone - Iodine solution 5%, ointment 5%, powder
Turpentine liniment
Urea ointment or cream 10%
White soft Paraffin
Whitfield Ointment (Salicylic acid 6% + Benzoic acid 3 %) cream or
oint.
Zinc Oxide Ointment

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